New tool allows researchers to track how mutations arise in tissues
Researchers at the MRC Weatherall Institute of Molecular Medicine and the German Cancer Research Center (DKFZ) have developed a new method to analyse how our tissues evolve as we age.
Read moreMRC Translational Immune Discovery Unit
Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.
MRC Molecular Haematology Unit
Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.
Centre for Computational Biology
Using computational biology to help understand complex biological systems and combat a range of human diseases.
Latest publications
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Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.
Journal article
Elliott N. et al, (2025), Blood
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Ruxolitinib in Patients With Corticosteroid-Refractory or Corticosteroid-Dependent Chronic Graft-Versus-Host Disease: 3-Year Final Analysis of the Phase III REACH3 Study.
Journal article
Zeiser R. et al, (2025), J Clin Oncol
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Iron deficiency causes aspartate-sensitive dysfunction in CD8+ T cells.
Journal article
Teh MR. et al, (2025), Nat Commun, 16
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Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Journal article
Brierley CK. et al, (2025), Nat Genet
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Engineering antisense oligonucleotides for targeted mRNA degradation through lysosomal trafficking.
Journal article
Kashyap D. et al, (2025), Chem Sci
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