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New research reveals druggable target arising from chromosomal rearrangement in aggressive leukaemia

Researchers at the University of Oxford have uncovered a potential new therapeutic target in a particularly aggressive and hard-to-treat form of leukaemia.

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Leading research with the aim of improving human health.

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Translating Our Research

Leading research with the aim of improving human health. World-leading research from scientists at the MRC WIMM has been developed into commercial ventures to translate our discoveries into clinics and benefit patients.

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Study identifies key immune structures in the gut that may drive coeliac disease

Researchers in Oxford have found structures of immune cells in the gut that may be driving the response to gluten in people with coeliac disease and could provide a target for future therapies.

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The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

Discover. Translate. Advance.

The MRC WIMM's core mission is to improve human health through the pursuit of fundamental research, the development of new technology, and the translation of discoveries to the clinic.

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Doctor checking a mole on a patient's back.

New study finds common virus may improve skin cancer treatment outcomes

A new study led by the Fairfax Group at the University of Oxford has revealed that a common and usually harmless virus may positively influence how skin cancer patients respond to current treatments.

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Research at the MRC WIMM spans 5 core areas.

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MRC WIMM Research Areas

Research at the MRC WIMM spans 5 core areas.

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MRC Translational Immune Discovery Unit

Pioneering the future in the study of human immunity to uncover the molecular pathways driving immune-mediated diseases.

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MRC Molecular Haematology Unit

Understanding how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders.

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Centre for Computational Biology

Using computational biology to help understand complex biological systems and combat a range of human diseases.

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Latest publications

Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A.
Journal article

Brierley CK. et al, (2025), Nat Genet
Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus study
Journal article

Hughes SE. et al, (2025), Eclinicalmedicine, 84
Oxford Classic-defined EMT risk stratification of High Grade Serous Ovarian cancer for guiding treatment decisions
Journal article

AHMED A., (2025), Clinical Cancer Research
Immune perturbation by the ileal microbiota in multiple sclerosis.
Journal article

Jensen LT. and Fugger L., (2025), Proc Natl Acad Sci U S A, 122
T cell memory response to MPXV infection exhibits greater effector function and migratory potential compared to MVA-BN vaccination.
Journal article

Chen J-L. et al, (2025), Nat Commun, 16

More Publications

Upcoming Seminars

Targeting Regulatory T cells in Cancer: Means, Mechanisms and New Therapies

Tuesday, 17 June 2025, 1pm to 2pm

Speakers: Professor Sergio Quezada
Spatially mapping immune mediated kidney disease

Thursday, 19 June 2025, 12pm to 1pm

Speakers: Dr Katherine Bull
Monogenic inflammatory bowel disease and autoimmune phenocopy.

Friday, 20 June 2025, 9.15am to 10.15am

Speakers: Professor Holm Uhlig
Co-inhibitory receptors promiscuously inhibit T cell activation

Friday, 27 June 2025, 9.15am to 10.15am

Speakers: Sofia Bustamante Eguiguren
Title TBC

Friday, 04 July 2025, 9.15am to 10.15am

Speakers: Shamsideen Yusuf, Dana Costigan

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MRC WIMM Interactive Timeline

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