Contact information
                        
                        
                            
                            irene.roberts@paediatrics.ox.ac.uk
                        
                        
                    
                        
                        
                            
                            Direct line (MRC Weatherall Institure of Molecular Medicine) 01865 222316
                            
                        
                        
                        
                        
                    
Irene Roberts
Emeritus Professor of Paediatric Haematology
- MRC Investigator, MRC Molecular Haematology Unit, MRC Weatherall Institute of Molecular Medicine
RESEARCH INTERESTS
I have a longstanding interest in understanding the developmentally-regulated, molecular and biological properties of fetal haematopoietic stem and progenitor cells (HSPC) that underlie the development of blood problems that affect babies and young children.
BACKGROUND
Irene Roberts qualified in medicine at Glasgow University, Scotland in 1978. After training in paediatrics and haematology and doctoral training in Garret FitzGerald's lab, Vanderbilt University, Nashville, she joined Lucio Luzzatto's lab at Imperial College London where she established her own group. She moved to the Department of Paediatrics and MRC Molecular Haematology Unit in the Weatherall Institute of Molecular Medicine, University of Oxford, in 2013.
OTHER ROLES
I am an Associate Editor of Blood and Vice-chair of the Scientific Committee on Blood Disorders in Childhood of the American Society for Hematology. I am also a member of the European Hematology Association Global Outreach Committee and formerly held senior positions in the Executive Board and a number of other constituted and ad hoc committees. I was previously an Honorary Consultant Paediatric Haematologist at Oxford University Hospitals NHS Trust and Imperial College Healthcare NHS Trust and Theme Lead for the Non-Malignant Haematological Disorders for the National Institute of Health Research (NIHR) Translational Research Collaboration Rare Diseases Collaboration.
Recent publications
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                Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.Journal article Smith A. et al, (2025), Blood 
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                Clinical significance of preleukemic somatic GATA1 mutations in children with Down syndrome.Journal article Elliott N. et al, (2025), Blood 
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                Genome-wide association study of somatic GATA1s mutations in newborns with Down Syndrome.Journal article Li Y. et al, (2025), Blood Adv 
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                Bi-specific CAR-iNKT cell immunotherapy for high-risk KMT2A-rearranged leukemia outperforms CAR-T in an NKG2D-dependent manner and eradicates leptomeningeal diseasePreprint Ren H. et al, (2025)