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We bring together biomedical, analytical and clinical expertise to shed new light on the causes that underpin neurodegenerative diseases.

Our research team, along with our local and international collaborators, aims to design tools for faster diagnosis, accurate prognosis, and to identify new targets for life-changing and life-saving treatments.

We are located in the Weatherall Institute for Molecular Medicine (WIMM) at the John Radcliffe Hospital. ​We collaborate closely with a wide range of scientists and clinicians and have close ties to the Broad Institute and the Karolinska Institutet.


  • Harness genetic information to facilitate the diagnosis of neurodegenerative diseases
  • Determine how environmental factors contribute to disease development and progression
  • Understand why disease presentation and prevalence varies across different ethnic populations
  • Determine whether drug efficacy, indications, and potential side effects can be predicted prior to clinical testing to help prioritise therapeutic  strategies that will likely confer the greatest benefit
  • Assess whether drugs already in use for other conditions can be repurposed to accelerate the treatment of neurodegenerative disease patients - without the need for lengthy clinical trials that can take decades factors contribute to disease development and progression

Our team

Selected publications

Front cover of Nature Journal Issue 625, 11th January 2024

Our funders

  • OAK Foundation
  • MRC
  • MS Society
  • Bristol Myers Squibb
  • Aims2Cure
  • Novartis

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affiliated external collaborators

Dr Lise Torp Jensen - Aarhus University

Dr Max Kaufmann - Clinical Research Fellow, University Medical Centre Hamburg

Dr Mihai Ancau - Neurologist and Postdoctoral Researcher, Technical Institute of Munich