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Sumana Sharma
Sir Henry Wellcome Postdoctoral Fellow
I am a Sir Henry Wellcome Postdoctoral fellow at the MRC Weatherall Institute of Molecular Medicine (WIMM). My general research interests are in understanding context-specific signalling in cells. My background is in characterising receptor interactions using genome-scale CRISPR/Cas9 screening approaches. More recently, I have also been using computational tools to characterise signalling from -omics datasets, specifically using large-scale vulnerability screens and protein-protein interaction networks. Currently, my research focuses on understanding immunomodulation by checkpoint inhibitory receptors on the surface of T-cells, for which I am using a range of CRISPR-based genome editing experimental and network-based computational approaches.
Key publications
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The current state and future of T-cell exhaustion research
Jenkins E. et al, (2023), Oxford Open Immunology, 4
Recent publications
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The Structural Biology of T-Cell Antigen Detection at Close Contacts.
Lui Y. et al, (2025), Immunol Rev, 331
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A high-throughput two-cell assay for interrogating inhibitory signaling pathways in T cells.
Sharma S. et al, (2024), Life Sci Alliance, 7
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ARID1A-induced transcriptional reprogramming rewires signalling responses to drug treatment in melanoma
Barker CG. et al, (2024)
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Cell state and transcription factor modulation during extended ex vivo CD8+T-cell expansion
Lui Y. et al, (2024)
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The current state and future of T-cell exhaustion research
Jenkins E. et al, (2023), Oxford Open Immunology, 4