portrait
Research groups
Pramila Rijal
DPhil
RDM Principal Investigator
- COI Career Development Fellow/ Group Leader
Antibodies, Vaccine and Drug against Influenza virus
Antibodies and Vaccine Development Against Infectious Viruses
Dr. Pramila Rijal is a researcher focused on infectious diseases, particularly Influenza and Ebola viruses. She received her Ph.D. from the University of Oxford in 2017, where she studied the human monoclonal antibody response to these viruses after natural infection and vaccination. With over ten years of research experience, Dr. Rijal has developed expertise in antibody and vaccine development. Her current work centres on the influenza neuraminidase (NA) protein, which is crucial for developing effective treatments and vaccines.
Research Focus
Dr. Rijal's research includes:
- Monoclonal Antibodies: Characterising the protective antibodies targeting NA protein
- Vaccine Development: Engineering the NA protein and developing NA-based nanoparticle vaccines with the aim of generating a broader and higher-quality antibody response
- Drug Discovery: Identifying new drugs that target the neuraminidase protein to advance antiviral therapies.
The funding support comes from the CAMS-Oxford Institute and the Novo-Nordisk Foundation.
https://www.rdm.ox.ac.uk/research/rijal-group
https://www.camsoxford.ox.ac.uk/research/groups/rijal-group
Recent publications
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A locally administered single-cycle influenza vaccine expressing a non-fusogenic stabilized hemagglutinin stimulates strong T-cell and neutralizing antibody immunity.
Journal article
Sadler HL. et al, (2025), J Virol
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A review of broadly protective monoclonal antibodies to treat Ebola virus disease.
Journal article
Rijal P. and Donnellan FR., (2023), Curr Opin Virol, 61
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A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern.
Journal article
Ertesvåg NU. et al, (2022), Commun Med (Lond), 2
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A Rapid Antibody Screening Haemagglutination Test for Predicting Immunity to Sars CoV-2 Variants of Concern
Preprint
Ertesvåg NU. et al, (2021)
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Two doses of SARS-CoV-2 vaccination induce more robust immune responses to emerging SARS-CoV-2 variants of concern than does natural infection.
Preprint
Skelly DT. et al, (2021)