Leonid Olender received his BSc and MSc degrees from Tel-Aviv University, Israel. During his MSc training at the lab of Michael Milyavsky, he investigated the mechanisms underlying DNA damage-induced apoptosis in human Haematopoietic Stem and Progenitor Cells exposed to ionizing radiation. He then moved to the Ben-Gurion University of the Negev in Beer-Sheva, also in Israel, for a PhD under the supervision of Roi Gazit. Working on his thesis there, he focused his efforts on attempts to improve the technical abilities for ex vivo manipulation of murine Haematopoietic Stem Cells (HSCs) and lineage-committed Haematopoietic Progenitors. At the MRC Molecular Haematology Unit (MRC Weatherall Institute of Molecular Medicine, Radcliffe Department of Medicine, University of Oxford), Leonid is a postdoctoral researcher in Adam Wilkinson's group. His primary interest is the investigation of the processes underlying epigenetic regulation and the ageing of HSCs.
Thapa R, Elfassy E, Olender L, Sharabi O, Gazit R. Rapid activation of hematopoietic stem cells. Stem Cell Res Ther. 2023 Jun 6;14(1):152. doi: 10.1186/s13287-023-03377-6. PMID: 37280691.
Sharabi O, Greenshpan Y, Ofir N, Ottolenghi A, Levi T, Olender L, Adler-Agmon Z, Porgador A, Gazit R. High throughput screen for the improvement of inducible promoters for tumor microenvironment cues. Sci Rep. 2022 May 3;12(1):7169. doi: 10.1038/s41598-022-11021-1. PMID: 35504918; PMCID: PMC9065017.
Olender L*, Thapa R*, Gazit R. Isolation of Murine Myeloid Progenitor Populations by CD34/CD150 Surface Markers. Cells. 2022 Jan 20;11(3):350. doi: 10.3390/cells11030350. PMID: 35159159; PMCID: PMC8834359.
Bujanover N, Thapa R, Goldstein O, Olender L, Sharabi O, Milsom MD, Gazit R. Hypersensitivity response has negligible impact on Hematopoietic Stem Cells. Stem Cell Reports. 2021 Aug 10;16(8):1884-1893. doi: 10.1016/j.stemcr.2021.06.013. Epub 2021 Jul 22. PMID: 34297939; PMCID: PMC8365095.
Olender L, Bujanover N, Sharabi O, Goldstein O, Gazit R. Cyclosporine H Improves the Multi-Vector Lentiviral Transduction of Murine Haematopoietic Progenitors and Stem Cells. Sci Rep. 2020 Feb 4;10(1):1812. doi: 10.1038/s41598-020-58724-x. PMID: 32020016; PMCID: PMC7000727.
Biechonski S, Olender L, Zipin-Roitman A, Yassin M, Aqaqe N, Marcu-Malina V, Rall-Scharpf M, Trottier M, Meyn MS, Wiesmüller L, Beider K, Raz Y, Grisaru D, Nagler A, Milyavsky M. Attenuated DNA damage responses and increased apoptosis characterize human hematopoietic stem cells exposed to irradiation. Sci Rep. 2018 Apr 17;8(1):6071. doi: 10.1038/s41598-018-24440-w. PMID: 29666389; PMCID: PMC5904119.
Biechonski S, Gourevich D, Rall M, Aqaqe N, Yassin M, Zipin-Roitman A, Trakhtenbrot L, Olender L, Raz Y, Jaffa AJ, Grisaru D, Wiesmuller L, Elad D, Milyavsky M. Quercetin alters the DNA damage response in human hematopoietic stem and progenitor cells via TopoII- and PI3K-dependent mechanisms synergizing in leukemogenic rearrangements. Int J Cancer. 2017 Feb 15;140(4):864-876. doi: 10.1002/ijc.30497. Epub 2016 Nov 22. PMID: 27813122.