Contact information
Collaborators
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Lars Fugger
Professor of Neuroimmunology
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Gabriele DeLuca
Professor of Clinical Neurology and Experimental Neuropathology
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Jacqueline Palace
Consultant Neurologist and Professor of Clinical Neurology
Kate Attfield
Principal Investigator
Physical and mental disability caused by neuroinflammation is a common clinical occurrence in many diseases, including multiple sclerosis (MS), Alzheimer’s disease and schizophrenia. However, the cause(s) of this inflammation and the devastating consequences that ensue are poorly defined, as reflected by a lack of effective treatments.
As demonstrated by our previous work, with a particular focus on multiple sclerosis, we have shown how studying individual cells directly from patient blood or mapping biological events across the diseased brain in post-mortem tissue, can expose an intricate network of neuroinflammatory processes, which change through time and space. With evolving technologies, our research team seeks to understand how the immune system and resident cells of the central nervous system orchestrate these disease processes.
Recent publications
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Antibody agonists trigger immune receptor signaling through local exclusion of receptor-type protein tyrosine phosphatases.
Lippert AH. et al, (2024), Immunity, 57, 256 - 270.e10