Felix A Radtke
My research experience includes studying neutrophil biology in homeostasis and inflammation in humans and mice and novel diagnostical methods for paediatric Lyme disease at Heidelberg University and the Brigham and Women’s Hospital, Harvard Medical School.
After graduating from medical school, I joined the Vyas lab to study haematopoiesis and haematological malignancies. During my time at Oxford, I am focusing my research on the mutational landscape of haematopoietic malignancies and identifying the transcriptomic and epigenetic landscape of patients with acute myeloid leukaemia treated with novel therapeutics. A particular interest is the transcriptomic state and the clonal architecture of TP53 mutations in AML.
By applying and improving novel sequencing technologies, the laboratory aims to understand the events leading to the development of acute myeloid leukaemia and to improve treatment opportunities.
I hold the Oxford – Sir David Weatherall Scholarship from Green Templeton College and am co-funded by the Radcliffe Department of Medicine/Weatherall Institute of Molecular Medicine (WIMM Prize Studentship). I am very grateful to the college and the institute for their support.
Ageing and interferon gamma response drive the phenotype of neutrophils in the inflamed joint.
Grieshaber-Bouyer R. et al, (2022), Annals of the rheumatic diseases, 81, 805 - 814
Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis.
Huang FY. et al, (2022), Blood advances, 6, 2081 - 2091
Serologic Response to Borrelia Antigens Varies with Clinical Phenotype in Children and Young Adults with Lyme Disease.
Radtke FA. et al, (2021), Journal of clinical microbiology, 59
The neutrotime transcriptional signature defines a single continuum of neutrophils across biological compartments.
Grieshaber-Bouyer R. et al, (2021), Nature communications, 12
Neutrophil transit time and localization within the megakaryocyte define morphologically distinct forms of emperipolesis
Huang FY. et al, (2021)