Catherine Chahrour
Postdoctoral Researcher in Computational Biology
My research focuses on identifying the DNA binding specificity of chromatin complexes in leukaemia. Specifically, how the MLL-AF4 fusion protein and proteins known to associate with MLL such as Menin bind to enhancers and if they have preference for specific DNA sequences.
I hold a BSc in Biology and a MSc in Applied Genomics from Imperial. Prior to joining the Milne group for my DPhil, I worked as a bioinformatician at the MRC London Institute of Medical Sciences.
Recent publications
The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.
Journal article
Ling RE. et al, (2026), Blood
MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia.
Journal article
Lau I-J. et al, (2026), Blood
Menin maintains enhancer-promoter interactions in a leukemia-specific manner
Preprint
Sharlandjieva V. et al, (2026)
FACT safeguards promoter topology by maintaining nucleosomes and restricting chromatin factor spreading
Preprint
Dopico-Fernandez A. et al, (2026)
A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment.
Journal article
Meaker GA. et al, (2025), Blood, 146, 3188 - 3200
Menin inhibitor DS-1594b drives differentiation and induces synergistic lethality in combination with venetoclax in acute myeloid leukemia cells with rearranged mixed-lineage leukemia and mutated nucleophosmin-1.
Journal article
Ciaurro V. et al, (2025), Haematologica