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Angus Groom

BSc Natural Sciences; MSc Stem cells and regeneration

DPhil Student

I joined the Vyas Lab in September 2021, having previously done a BSc in Natural Sciences at Durham University and an MSc in Stem Cells and Regeneration at Bristol University. I am a DPhil student supported by the Lady Tata Memorial Trust.

My research focuses on a common age-associated condition called clonal haematopoiesis, which occurs in healthy older people but carries an increased risk of AML and other myeloid malignancies. Somatic mutations in epigenetic regulators can lead to aberrant clonal expansion and disruption of normal haematopoiesis. I am particularly interested in the histone modifier ASXL1, and how mutations in this gene lead to an imbalance of haematopoietic stem and progenitor cells within the bone marrow. Perturbed histone modification can lead to disruption of gene expression. Identifying which genes and pathways are disrupted can help us understand the very first stages of leukaemia development and help inform novel therapeutic targets.

Prior to joining the WIMM, I had a career as a professional athlete in the GB Rowing Team spanning 8 years. During this time I was lucky enough to compete at both the Rio 2016 and Tokyo 2020 Olympic Games in the men's quadruple scull for Team GB.