Prof Lars Fugger

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Neurodegeneration in multiple sclerosis. An axon (yellow) is being destroyed by a macrophage (purple).

Neurodegeneration in multiple sclerosis. An axon (yellow) is being destroyed by a macrophage ...

Multiple sclerosis (MS) is a common chronic inflammatory and neurodegenerative disease of the central nervous system.

Inherited susceptibility to MS is primarily associated with certain MHC genes. In addition, unknown environmental factors also seem to play a role in the disease.

Our group is seeking to understand the molecular basis for the MHC association in MS and how MHC genes interact with environmental factors such as viruses.

We are also investigating how the MHC associated inflammation leads to neurodegeneration, which is responsible for the long-term disability in MS patients.

We are taking a multidisciplinary approach, which is possible through a strong network of local and international collaborators.

There is a strong focus on translational medicine and both clinicians and non-clinicians are working in the group.

The goal is to use the combined knowledge to develop new drugs for the treatment of MS.

Current studies focus on:

The development of humanized animal models of MS that express human autoimmunity genes in collaboration with Professor John Bell at the University of Oxford.

Structural and biophysical studies of disease associated MHC molecules and T cell receptors in collaboration with Prof. Anton van der Merwe and Prof. Yvonne Jones at University of Oxford.

Neuropathological studies of MS lesions in collaboration with Prof. Margaret Esiri at University of Oxford.

Neurodegenerative studies of MS in collaboration with Prof. Angela Vincent at University of Oxford.

Clinical studies MS in collaboration with Dr. Jackie Palace in The Department of Clinical Neurology at John Radcliffe Hospital.

There are no collaborations listed for this principal investigator.

There are no publications listed for this principal investigator.