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An increased frequency of human leukocyte antigen (HLA)-DR1 was found in 49 non-immunosuppressed patients with non-melanoma skin cancer (NMSC), being highest in patients under the age of 60 with multiple squamous cell carcinomas (SCC). Of 266 patients receiving long-term immunosuppression following renal transplantation 46 (17%) were found to have NMSC. No increase in HLA-DR1 was found in renal transplant recipients (RTR) with non-melanoma skin cancer (RTR+C) when compared with matched renal transplant recipients without skin cancer (matched RTR-C), or when compared with healthy controls. There was an increased frequency of DQw2 in RTR+C, most pronounced in RTR with SCC (61.9% compared with 18.75% in matched RTR-C), giving a relative risk of 13.98. We found statistically significant differences in the frequency of a number of HLA antigens on comparing RTR+C with healthy controls, but none of these differences were found when we compared RTR+C against matched RTR-C.

Original publication

DOI

10.1016/s0959-8049(05)80143-1

Type

Journal article

Journal

Eur J Cancer

Publication Date

1993

Volume

29A

Pages

520 - 524

Keywords

Antigens, Neoplasm, Carcinoma, Basal Cell, Carcinoma, Squamous Cell, Female, HLA Antigens, HLA-DQ Antigens, HLA-DR1 Antigen, Humans, Immunosuppression, Kidney Transplantation, Male, Middle Aged, Postoperative Complications, Risk Factors, Skin Neoplasms