Kusumbe Lab | Tissue and Tumor Microenvironments

Vascular & ImmUNE SYSTEM AGEING

Blood and lymphatic vessels form a versatile transport network. In addition to their conventional role as a transport system, vessels form niches for stem and progenitor cells and provide signals to maintain tissue functions. Vasculature also plays a fundamental role in supporting immune cell survival and transport. But how blood and lymphatic vessels change over time and how vascular ageing impacts the immune system, tissue and systemic ageing are not known. As opposed to the previously considered homogenous nature of vessels, recent evidence indicates the diversity of blood vessels across different tissues. Previous work shows that the skeletal system harbours specialized blood vessels (type H vessels) that drive bone formation; however, these vessels decline in ageing, leading to loss of bone mass. Blood stem cells residing in bone give rise to immune cells. Ageing is associated with a decline in the immune system and tissue functions. We examine vascular diversity and vascular changes over time with the aim of identifying therapeutic targets for ageing and immune system-associated diseases. We exploit cutting-edge 3D and 4D imaging to understand vascular and immune cell interactions over time and across diverse tissue and tumour microenvironments.

IMAGING

The lab has developed and proactively shared imaging methods and tools and has generated and made available image databases as open resources for the scientific community. The lab leads the organization of the Annual Oxford Imaging Symposium and the Annual Vascular Biology Symposium. The lab collaborates closely with Miltenyi Bioteec to advance tissue imaging. Kusumbe led the set-up of the 3D tissue imaging, light sheet imaging of cleared tissues and contributed to funding acquisition which laid the foundation for the current Oxford-Zeiss Centre of Excellence (Zeiss CoE).

SUSTAINABILITY & EFFICIENCY IN RESEARCH

The lab received the 2022 GOLD Award in recognition of exemplary actions undertaken to improve sustainability and efficiency practices as part of the laboratory Efficiency Assessment Framework (LEAF).  https://www.imm.ox.ac.uk/news/gold-leaf-award-for-kusumbe-lab

RecruitmenT

Positions Available:

Postdoc applicants: Doctoral scientists interested in joining the Kusumbe lab should contact Anjali. You should have published the first-author paper/s.

Visiting students: Prospective students interested in our lab should contact Anjali with their CV and scientific interests to inquire.