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We have prepared monoclonal antibodies by immunizing BALB/c mice with purified human term placental plasma membranes. The antibodies were selected to show predominant specificity for trophoblast and trophoblast derivatives. Four of these antibodies have been found to recognize the placenta-specific isozyme of alkaline phosphatase (EC 3.1.3.1), and to cross-react with the closely related testis form of this enzyme. One antibody recognized transferrin, a serum protein with an abundant placental receptor. The specificities of the other antibodies, whose target antigens are unknown, are described. Their reactivity with some human tumour-derived epithelial cell lines suggests that they may provide useful markers of human trophectoderm differentiation, as well as for properties selected for during tumour progression.

Original publication

DOI

10.1002/ijc.2910330514

Type

Journal article

Journal

Int J Cancer

Publication Date

15/05/1984

Volume

33

Pages

633 - 641

Keywords

Alkaline Phosphatase, Animals, Antibodies, Monoclonal, Epitopes, Female, Humans, Male, Mice, Mice, Inbred BALB C, Placenta, Testicular Neoplasms, Transferrin, Trophoblasts