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The fundamental ideas on the causes of cancer have been known for some time. They can now be interpreted in terms of the notion that cancer is essentially a genetic disease at the cellular level. The aim of this introductory article is to provide a brief overview of these ideas and the evidence for them, as well as some of the implications for future approaches to the prevention, early detection and treatment of cancer.

Original publication




Journal article


Br Med Bull

Publication Date





517 - 526


Family, Genes, Tumor Suppressor, Humans, Neoplasms, Oncogenes, Philadelphia Chromosome, Translocation, Genetic