The collaboration has led to the first pre-clinical model of acute erythroid leukaemia.
Acute erythroid leukemia commonly involves both myeloid and erythroid lineage transformation. Di Genua et al. show that combined Cebpa and Gata2 mutations induce bi-lineage AEL. The Gata2 mutation (bottom soil layer) increases chromatin accessibility of erythroid transcription factor motifs (red roots) and decreases chromatin accessibility of myeloid transcription factor motifs (blue roots) while bi-allelic Cebpa mutation (top soil layer) increases erythroid transcription factor expression. This transforms neutrophil-monocyte progenitors into bi-potent leukemia-initiating cells that produce both myeloid and erythroid blasts (red and blue flowers, respectively). Artwork by Rae Cook.
MRC TIDU
Researchers
DPhil Yi-Ling Chen - Career Development Fellow
MRC TIDU
Researchers
DPhil Pramila Rijal - Career Development Fellow
Researchers
Samuel Jones - Postdoctoral Researcher
MRC TIDU
Researchers
Anne Bridgeman - Senior Research Assistant
Facilities Staff
John Frankland - Sequencing Technician
MRC TIDU
Researchers
Clare Hardman - Senior Postdoctoral Scientist
Group Leaders
MRC TIDU
B.A. (Natural Sciences), Ph.D. (Biochemistry) David Jackson - Professor of Human Immunology
Group Leaders
MRC MHU
MRCPCH FRCPath PhD Anindita Roy - Professor of Paediatric Haematology
MRC TIDU
Researchers
Yuan Lui - Postdoctoral Research Fellow
Group Leaders
MRC TIDU
FMedSci Graham Ogg - Professor of Dermatology
Group Leaders
MRC TIDU
PhD Jan Rehwinkel - Professor of Innate Immunology
MRC TIDU
Support Staff
Lisa Schimanski - Research Assistant
MRC TIDU
Support Staff
Renata Sojka - PA to Professor Alison Simmons
Group Leaders
MRC TIDU
FRS FRCP Alain Townsend - Emeritus Professor of Molecular Immunology
MRC TIDU
Support Staff
Mai Vuong - Research Assistant
Group Leaders
MRC MHU
MA; MBBS; MRCP; FRCPath; PhD Bethan Psaila - Associate Professor of Haematology
MRC MHU
Researchers
Yavor Bozhilov - Postdoctoral Researcher
MRC MHU
Researchers
PhD Melinda Czéh - CRUK Clinical Scientist
MRC MHU
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PhD Roy Drissen - Postdoctoral Researcher
MRC MHU
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BSc (Hons), Postgraduate Certificate in Clinical Cytogenetics Jill Brown - Research Assistant
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