The collaboration has led to the first pre-clinical model of acute erythroid leukaemia.
Acute erythroid leukemia commonly involves both myeloid and erythroid lineage transformation. Di Genua et al. show that combined Cebpa and Gata2 mutations induce bi-lineage AEL. The Gata2 mutation (bottom soil layer) increases chromatin accessibility of erythroid transcription factor motifs (red roots) and decreases chromatin accessibility of myeloid transcription factor motifs (blue roots) while bi-allelic Cebpa mutation (top soil layer) increases erythroid transcription factor expression. This transforms neutrophil-monocyte progenitors into bi-potent leukemia-initiating cells that produce both myeloid and erythroid blasts (red and blue flowers, respectively). Artwork by Rae Cook.
Group Leaders
MRC MHU
Irene Roberts - Emeritus Professor of Paediatric Haematology
Group Leaders
MRC MHU
MA; MBBS; MRCP; FRCPath; PhD Bethan Psaila - Associate Professor of Haematology
MRC MHU
Researchers
Yavor Bozhilov - Postdoctoral Researcher
MRC MHU
Researchers
PhD Melinda Czéh - CRUK Clinical Scientist
MRC MHU
Researchers
PhD Roy Drissen - Postdoctoral Researcher
MRC MHU
Researchers
BSc (Hons), Postgraduate Certificate in Clinical Cytogenetics Jill Brown - Research Assistant
MRC MHU
Researchers
MBChB; BSc; DPhil; MRCP; FRCPath Noemi Roy - Associate Professor of Molecular Haematology
MRC MHU
Researchers
BSc (Hons); PhD Caroline Scott - Research Assistant
Facilities Staff
MRC MHU
Researchers
PhD, Dipl-Biol. Jana Koth - Imaging Facility Manager
Group Leaders
MRC MHU
PhD Thomas Milne - Professor of Haematology
MRC MHU
Researchers
Sarah Gooding - Clinician Scientist
MRC MHU
Researchers
BMBCh, MRCP, DPhil Asger Jakobsen - Postdoctoral Clinical Research Fellow
Facilities Staff
MRC MHU
BSc, MSc Marlen Metzner - Next Generation Sequencing Lead
Group Leaders
MRC MHU
MRCP FRCP FRCPath Paresh Vyas - Professor of Haematology
Group Leaders
MRC MHU
PhD, M.D. Sten Eirik W. Jacobsen - Bass Professor of Developmental and Stem Cell Biology
MRC MHU
Students
Matthew Gosden - DPhil Student
Centre for Computational Biology
Group Leaders
MRC MHU
Jim Hughes - Professor of Gene Regulation
MRC MHU
Researchers
PhD-Cancer Biology, Vanderbilt University; BS-Recombinant Genetics & Chemistry, Western Kentucky University Natalina Elliott - Postdoctoral Researcher
Group Leaders
MRC MHU
MRCPCH FRCPath PhD Anindita Roy - Professor of Paediatric Haematology
Group Leaders
MRC MHU
FRS FMedSci KJ Patel - MRC WIMM Director, MRC MHU Director
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