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New collaborative research from MRC WIMM researchers and the Mommersteeg Group in the Department of Physiology, Anatomy & Genetics at the University of Oxford shows that a protein called Runx1 plays a significant role in the formation of the cardiac scar that forms after the heart is injured, a scar that is known to inhibit heart regeneration. In the zebrafish, a freshwater fish known to be able to fully regenerate its heart after damage, they show that the absence of Runx1 results in enhanced regeneration. This indicates a potential new therapeutic target for heart repair.
Anindita Roy
Group Leaders MRC MHU
MRCPCH FRCPath PhD Anindita Roy - Professor of Paediatric Haematology
Asger Jakobsen
MRC MHU Researchers
BMBCh, MRCP, DPhil Asger Jakobsen - Postdoctoral Clinical Research Fellow
Sten Eirik W. Jacobsen
Group Leaders MRC MHU
PhD, M.D. Sten Eirik W. Jacobsen - Bass Professor of Developmental and Stem Cell Biology
Jim Hughes
Centre for Computational Biology Group Leaders MRC MHU
Jim Hughes - Professor of Gene Regulation
Natalina Elliott
MRC MHU Researchers
PhD-Cancer Biology, Vanderbilt University; BS-Recombinant Genetics & Chemistry, Western Kentucky University Natalina Elliott - Postdoctoral Researcher
Tatjana Sauka-Spengler
Group Leaders
Tatjana Sauka-Spengler - Professor of Developmental Genomics and Gene Regulation
David Jackson
Group Leaders MRC TIDU
B.A. (Natural Sciences), Ph.D. (Biochemistry) David Jackson - Professor of Human Immunology