MRC Molecular Haematology Unit
We aim to understand how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders. Ultimately, our purpose is to improve the prognosis of patients with inherited and acquired blood diseases.
Bi-directional signaling by membrane-bound KitL induces proliferation and coordinates thymic endothelial cell and thymocyte expansion.
Buono M. et al, (2018), Nat commun, 9
Oudelaar AM. et al, (2018), Nat genet
A tissue-specific self-interacting chromatin domain forms independently of enhancer-promoter interactions.
Brown JM. et al, (2018), Nat commun, 9
Small molecule inhibitors of RAS-effector protein interactions derived using an intracellular antibody fragment.
Quevedo CE. et al, (2018), Nat commun, 9
Truch J. et al, (2018), Methods mol biol, 1832, 105 - 130