MRC Molecular Haematology Unit
We aim to understand how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders. Ultimately, our purpose is to improve the prognosis of patients with inherited and acquired blood diseases.
Sensitive, rapid diagnostic test for transient abnormal myelopoiesis and myeloid leukemia of Down syndrome.
Cruz Hernandez D. et al, (2020), Blood, 136, 1460 - 1465
Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.
Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9
Micro-environmental sensing by bone marrow stroma identifies IL-6 and TGFβ1 as regulators of hematopoietic ageing.
Valletta S. et al, (2020), Nat Commun, 11