MRC Molecular Haematology Unit
We aim to understand how mature blood cells are normally made from stem cells and how this is perturbed in common blood disorders. Ultimately, our purpose is to improve the prognosis of patients with inherited and acquired blood diseases.
Discovery of a CD10-negative B-progenitor in human fetal life identifies unique ontogeny-related developmental programs.
O'Byrne S. et al, (2019), Blood, 134, 1059 - 1071
Babbs C. et al, (2020), J Med Genet, 57, 414 - 421
A revised model for promoter competition based on multi-way chromatin interactions at the α-globin locus.
Oudelaar AM. et al, (2019), Nat Commun, 10
Single-cell analysis of bone marrow-derived CD34+ cells from children with sickle cell disease and thalassemia.
Hua P. et al, (2019), Blood, 134, 2111 - 2115