MRC Human Immunology Unit

Spatial transcriptomics of neurodegeneration in Progressive Multiple Sclerosis (MS)

In a paper published in Nature Neuroscience, the Fugger Group describe molecular pathways of MS neurodegeneration in unprecedented detail.

Three people stand next to the sign outside the MRC WIMM at the University of Oxford.

Understanding the interplay of dietary iron, anaemia and the immune system

Four related projects aim to unravel how the iron we eat shapes how the immune system develops and responds to vaccines.

MRC HIU scientists in Horizon Prize winning team

Alain Townsend, Tiong Kit Tan and Pramila Rijal among those awarded the Chemistry Biology Interface Division Horizon Prize by the Royal Society of Chemistry.

Funding awarded for autoimmune disease research

Dr Kate Attfield awarded project funding by Connect Immune Research and The Lorna and Yuti Chernajovsky Biomedical Research Foundation.

Confocal microscopy of a lung section, 4 days after being rechallenged with an influenza virus. Resident memory B cells (red) and newly generated plasma cells (yellow) can be seen in very close proximity to infected cells (light blue).

Defining the role of resident memory B cells in the fight against influenza

Researchers at the Kennedy Institute of Rheumatology and the MRC Human Immunology Unit have used 3D and live-imaging to show how resident memory B cells boost antibodies to fight influenza.

At the MRC Human Immunology Unit we propel the understanding and treatment of immune mediated diseases.

MRC HIU includes 16 research teams with over 160 scientists who share a common goal - to harness the immune system to enhance human health.

About the MRC HIU

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MRC HIU Research Groups

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Blue 3D rendering of coronavirus particles

CORONAVIRUS RESEARCH

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Researchers discuss academic posters at the HIU Day.

MRC HIU People

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FULL MRC HIU SEMINAR LIST

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Public Engagement

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Collaboration and innovation lie at the heart of the MRC HIU. Our research groups work together to understand how the human immune system functions, what happens when it fails, and how we can use our knowledge of these systems to improve patient outcomes. By working together with clinicians, industry and charities, we aim to translate our scientific findings at the HIU so that they can have a positive impact on global health. - Professor Alison Simmons

MRC HIU Director- Professor Alison Simmons

Alison Simmons

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RECENT PUBLICATIONS

Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.

MacLean AJ. et al, (2022), Immunity

MRC Human Immunology Unit

Spatial transcriptomics of neurodegeneration in Progressive Multiple Sclerosis (MS)

Understanding the interplay of dietary iron, anaemia and the immune system

MRC HIU scientists in Horizon Prize winning team

Funding awarded for autoimmune disease research

Defining the role of resident memory B cells in the fight against influenza

About the MRC HIU

MRC HIU Research Groups

CORONAVIRUS RESEARCH

MRC HIU People

FULL MRC HIU SEMINAR LIST

Public Engagement

MRC HIU Director- Professor Alison Simmons

Secondary influenza challenge triggers resident memory B cell migration and rapid relocation to boost antibody secretion at infected sites.

Competition for refueling rather than cyclic reentry initiation evident in germinal centers.

A Highly Fluorescent Dinuclear Aluminium Complex with Near-Unity Quantum Yield.

Ein stark fluoreszierender zweikerniger Aluminiumkomplex mit nahezu 100 %iger Quantenausbeute**

HLA-dependent variation in SARS-CoV-2 CD8+ T cell cross-reactivity with human coronaviruses.