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Search results (68)

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Metabolite-induced DNA damage drives stochastic stem cell loss and clonal hematopoiesis.

Kamimae-Lanning AN. et al, (2026), Cell Stem Cell

DNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs.

van der Sluijs RV. et al, (2025), Nucleic Acids Res, 53

Embracing cancer complexity: Hallmarks of systemic disease.

Swanton C. et al, (2024), Cell, 187, 1589 - 1616

Aldehyde-mediated inhibition of asparagine biosynthesis has implications for diabetes and alcoholism.

John T. et al, (2024), Chem Sci, 15, 2509 - 2517

Formaldehyde regulates S-adenosylmethionine biosynthesis and one-carbon metabolism.

Pham VN. et al, (2023), Science, 382

Genotoxic aldehyde stress prematurely ages hematopoietic stem cells in a p53-driven manner.

Wang M. et al, (2023), Mol Cell, 83, 2417 - 2433.e7

A histone deacetylase 3 and mitochondrial complex I axis regulates toxic formaldehyde production.

Wit N. et al, (2023), Sci Adv, 9

Efficient Synthesis of DNA Duplexes Containing Reduced Acetaldehyde Interstrand Cross-Links.

Morton SB. et al, (2023), J Am Chem Soc, 145, 953 - 959

Genotoxic aldehydes in the hematopoietic system.

Wang M. et al, (2022), Blood, 139, 2119 - 2129

Aldehyde-driven transcriptional stress triggers an anorexic DNA damage response.

Mulderrig L. et al, (2021), Nature, 600, 158 - 163

Two Aldehyde Clearance Systems Are Essential to Prevent Lethal Formaldehyde Accumulation in Mice and Humans.

Dingler FA. et al, (2020), Mol Cell, 80, 996 - 1012.e9

Amino acid dependent formaldehyde metabolism in mammals.

Pietzke M. et al, (2020), Commun Chem, 3

FANCD2-FANCI is a clamp stabilized on DNA by monoubiquitination of FANCD2 during DNA repair.

Alcón P. et al, (2020), Nat Struct Mol Biol, 27, 240 - 248

Alcohol-derived DNA crosslinks are repaired by two distinct mechanisms.

Hodskinson MR. et al, (2020), Nature, 579, 603 - 608

Structure of the Fanconi anaemia monoubiquitin ligase complex.

Shakeel S. et al, (2019), Nature, 575, 234 - 237

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