Search results (197)
« Back to PublicationsInhibition of MLLT1 limits growth of KMT2A::AFF1 leukaemias without killing healthy haematopoietic stem cells.
Journal article
Rajhansa S. et al, (2026), Exp Hematol
The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.
Journal article
Ling RE. et al, (2026), Blood
Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways.
Journal article
Chiu H. et al, (2026), Blood
Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.
Journal article
Chen LY. et al, (2026), Blood
MYB activity drives emergent enhancer activation and enhancer-promoter interactions in acute lymphoblastic leukemia.
Journal article
Lau I-J. et al, (2026), Blood
Correction to "DNA-Programmable Protein Degradation: Dynamic Control of Proteolysis-Targeting Chimera Activity via DNA Hybridization and Strand Displacement".
Journal article
Kashyap D. et al, (2026), JACS Au, 6, 653 - 655
Menin maintains enhancer-promoter interactions in a leukemia-specific manner
Preprint
Sharlandjieva V. et al, (2026)
Off-the-shelf dual CAR-iNKT cell immunotherapy eradicates medullary and leptomeningeal high-risk KMT2A-rearranged leukemia.
Journal article
Ren H. et al, (2026), Blood, 147, 180 - 196
FACT safeguards promoter topology by maintaining nucleosomes and restricting chromatin factor spreading
Preprint
Dopico-Fernandez A. et al, (2026)
A genome-wide screen identifies Runx2 as a novel regulator of hematopoietic stem cell expansion and T-cell commitment.
Journal article
Meaker GA. et al, (2025), Blood, 146, 3188 - 3200
Zone Equalisation Normalisation For Improved Alignment of Epigenetic Signal
Preprint
Wilson T. et al, (2025)
Mapping chromatin structure at base-pair resolution unveils a unified model of cis-regulatory element interactions.
Journal article
Li H. et al, (2025), Cell, 188, 7175 - 7193.e19
Small proteins with a big job: An EMBOW-derived microprotein targets WDR5-MLL1 and suppresses transcription in leukemia.
Journal article
Baillie HL. and Milne TA., (2025), Cell Chem Biol, 32, 1305 - 1307
Menin inhibitor DS-1594b drives differentiation and induces synergistic lethality in combination with venetoclax in acute myeloid leukemia cells with rearranged mixed-lineage leukemia and mutated nucleophosmin-1.
Journal article
Ciaurro V. et al, (2025), Haematologica
Enhancer heterogeneity in acute lymphoblastic leukemia drives differential gene expression in patients.
Journal article
Smith AL. et al, (2025), Blood, 146, 2073 - 2087