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Professor Jan Rehwinkel’s team from the MRC Human Immunology Unit have found that human cells use viruses as Trojan horses, transporting a messenger that encourages the immune system to fight the very virus that carries it. The discovery could have implications for the design of new vaccines.
CAR T cell therapy selectively depletes disease-driving mutant calreticulin cells in xenotransplants and human organoid models of myelofibrosis.
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Rampotas A. et al, (2026), Sci Transl Med, 18
TiO2 Alternative Coatings for Ferric Pyrophosphate Premixes: Stability and Bioaccessibility Relative to Ferrous Fumarate
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Teichman DL. et al, (2026), Innovative Food Science and Emerging Technologies, 111
ChatMDV: Reducing Technical Barriers in Bioinformatics Analysis using Large Language Models.
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Kiourlappou M. et al, (2026), Gigascience
IL-4 peptide hydrogel reprograms MSC heterogeneity toward the CD106+ population for enhanced renal repair.
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Pan K. et al, (2026), Proc Natl Acad Sci U S A, 123
Development of a recombinant single-cycle influenza viral vector as an intranasal vaccine against SARS-CoV-2.
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Munro J. et al, (2026), Sci Rep
Multiome-based identification of molecular markers for prospective identification of platelet-biased HSCs.
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Zhang B. et al, (2026), Stem Cell Reports
Positive allosteric modulator selective for adult muscle nicotinic acetylcholine receptor.
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Webster RG. et al, (2026), Proc Natl Acad Sci U S A, 123
Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention
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AHMED A., (2026), Nature Communications
Transmission ratio distortion of NF1 mutant alleles in familial Neurofibromatosis type 1
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Pei Y. et al, (2026), Genetics in Medicine
Inhibition of MLLT1 limits growth of KMT2A::AFF1 leukaemias without killing healthy haematopoietic stem cells.
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Rajhansa S. et al, (2026), Exp Hematol
Nucleophagy removes cytotoxic trapped PARP1.
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Hoslett G. et al, (2026), Nat Cell Biol
Beyond ATRX: The heterogeneous basis of Alternative Lengthening of Telomeres in osteosarcoma.
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Goncalves T. et al, (2026), Cancer Genet, 306-307, 123 - 129
Spermidine Mitigates Immune Cell Senescence and Boosts Vaccine Responses in Healthy Older Adults-A Pilot Study.
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Alsaleh G. et al, (2026), Aging Cell, 25
Lethal plague outbreaks in Lake Baikal hunter-gatherers 5,500 years ago.
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Macleod R. et al, (2026), Nature, 654, 697 - 705
Clinical Equipoise and Unimproved Outcomes following Posttransplant Cutaneous Squamous Cell Carcinoma.
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Crisp THJ. et al, (2026), Kidney Int Rep, 11
FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos
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Ding C. et al, (2026), Cell Insight, 5
Patterns of testing and the high burden of iron deficiency anemia in cirrhosis: a national cohort study
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Maynard S. et al, (2026), Blood Red Cells & Iron, 2, 100070 - 100070
The fetal specific gene LIN28B is essential for human fetal B-lymphopoiesis and initiation of KMT2A::AFF1 infant leukemia.
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Ling RE. et al, (2026), Blood
MAFF regulates ferroptotic sensitivity through iron homeostasis and fatty acid synthesis.
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Vilaplana Lopera N. et al, (2026), Cell Death Dis
Human haematopoietic stem cells remember inflammatory stress.
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Zeng AGX. et al, (2026), Nature