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Found 9666 matches for
Skin Immunology Group
The aim of the group is to understand, at the molecular and cellular level, the role of human cutaneous immune responses in mechanisms of disease, treatment and vaccination. We have a particular focus on T cells which recognise inflammatory lipids presented by CD1a. As well as contributing to an understanding of disease pathogenesis, we aim to translate our findings to changes in clinical practice.
RAMADAN GROUP
DNA Damage Response
Dong Group | T cell responses against Viruses & Cancer
Our group focuses on determining the factors which affect T cells both in the control of viral infection and in the development of cancer.
Koohy Group: Machine Learning and Integrative Approaches in Immunology
We would like to understand the functional and molecular mechanisms of the immune system in various immunologically important conditions such as cancer, infection, autoimmune disease as well as ageing. We have a special interest in computational cancer immunotherapy such as antigen presentation, neo-antigen identification and T cell recognition of neo-antigens as well as interrogating the immune response to personalized vaccines from neo-antigens.
de Bruijn Group: Developmental Haematopoiesis
We study the embryonic origins of blood stem cells with the aim to inform the generation of these cells in culture, and ultimate produce clinically relevant blood stem cells for therapeutic purposes.
Psaila Group: Megakaryocytes, Platelets and Myeloproliferative Neoplasms
We focus on four key areas: (1) Dissecting how blood cancers create 'self-reinforcing' niches that promote clonal expansion and protect malignant clones from immunotherapies; (2) Development and application of human bone marrow organoids to study normal and malignant haematopoiesis and validate targets in a relevant tissue microenvironment; (3) Developing novel strategies to selectively target cancer stem cells and pathological megakaryocytes in myelofibrosis, a severe bone marrow malignancy; (4) Understanding our recent discovery that platelets contain a repertoire of DNA fragments sequestered from cell free DNA, and confirming clinical utility for cancer detection and for pre-natal diagnosis.
Simmons Group: Intestinal Immunity in Health and Disease
We define how the immune system functions in the intestine to promote health. We uncover the immune pathogenesis of intestinal diseases such as inflammatory bowel disease to develop better ways to treat these disorders.
Chakraverty Group: Haematopoietic Transplantation and Immunotherapy
Our group is interested in developing novel immunotherapeutic approaches for leukaemia. Clinical approaches currently used include allogeneic haematopoietic stem cell transplantation, chimeric antigen receptor T cell therapy and immune checkpoint inhibitors. While each of these approaches can be successful, they also fail in many patients as a result of tumour adaptations or diminished function of immune cells. Enhanced immunity can also lead to immune-related adverse events due to on- or off-target effects. We are exploring the mechanisms that underpin these failures and using this information to devise new strategies that can be translated into early phase clinical trials.
Childhood Leukaemia Research Group
Founded in 2015, we are investigating the link between human fetal haematopoiesis and the origin and biology of childhood leukaemia. In particular, we are interested in the pathogenesis of infant leukaemia, which is a refractory disease that invariably originates in utero.
Mead Group: Normal and Malignant Haematopoietic Stem Cell Biology
The Mead Lab pioneers research into myeloid neoplasms using cutting-edge single-cell genomics and multiomics to uncover novel therapeutic targets. Our ultimate goal is to translate discoveries from the lab through to patient benefit, including interaction with industry and clinical trials. We foster a collaborative and dynamic environment for innovative science, with a focus on career development for members of the team.
Davies Group: Genomics and Clinical Genome Editing
We are primarily interested in understanding how the genome functions and to leverage this to develop novel genome editing based cellular therapies
Patel Group: Two tier protection and metabolic genotoxicity during blood production
We study endogenous DNA damage caused by metabolites and their impact on the function of vertebrate stem cells and the ageing process
Sims Group: Computational Genomics
We are a computational biology research group using genomic and functional genomic data to study transcriptional regulation, with projects spanning from neuroscience to musculoskeletal biology.
Hughes Group: Genome Biology
Using genomics, computational and synthetic biology approaches to understand how genes are regulated in health and disease.
Nerlov Group: Hematopoietic Stem Cell Genetics
Hematopoietic stem cell (HSC) transplantation is the only stem cell therapy in routine clinical use, and it is also the cell type that gives rise to most blood cancers. We use single cell biology and genetics to understand how hematopoietic stem cells normally sustain blood formation, and how this process is altered during ageing and when leukemia develops.
Ho Group: Translational Lung Immunology
Immune mechanisms of lung injury, regeneration and fibrosis; identifying new therapeutic targets, and improved treatment for idiopathic pulmonary fibrosis and sarcoidosis.
Neuromuscular Disorders
We work to translate an understanding of the molecular mechanisms of disease at the neuromuscular synapse into treatments. Our work led us to be commissioned to provide a National Advisory and Diagnostic Service for congenital myasthenic syndromes.