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Probes for restriction fragment length polymorphisms mapping between Xp21 and Xq22.3 have been used in a linkage study of incontinentia pigmenti (IP). Six independent sporadic cases of disorders resembling IP with X-autosome translocations involving the same X chromosome breakpoint (Xp11) have been reported. These observations suggest that the IP gene may be located in the Xp11 chromosomal region. However, the linkage study with DNA probes has failed to confirm this localisation.

Original publication

DOI

10.1111/j.1399-0004.1988.tb02607.x

Type

Journal article

Journal

Clin Genet

Publication Date

07/1988

Volume

34

Pages

1 - 6

Keywords

Chromosome Mapping, Genes, Dominant, Genetic Linkage, Humans, Incontinentia Pigmenti, Pedigree, Pigmentation Disorders, Polymorphism, Genetic, Polymorphism, Restriction Fragment Length, Translocation, Genetic, X Chromosome