Uncovering a new cellular origin for acute myeloid leukemia with lineage plasticity.

Czeh M., Rosenbauer F.

Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of human AML with gene expression profile suggesting T-lymphoid origin and potentially novel treatment.

DOI

10.1080/23723556.2016.1268241

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2017

Volume

4

Keywords

Leukemia, T-cell progenitors, lineage plasticity, myeloid differentiation

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