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Although acute myeloid leukaemia (AML) is assumed to be driven by transformed haematopoietic stem and progenitor cells, we have described recently a new pathway leading to AML from T-cell progenitors. Furthermore, we could identify a subgroup of human AML with gene expression profile suggesting T-lymphoid origin and potentially novel treatment.

Original publication

DOI

10.1080/23723556.2016.1268241

Type

Journal article

Journal

Mol Cell Oncol

Publication Date

2017

Volume

4

Keywords

Leukemia, T-cell progenitors, lineage plasticity, myeloid differentiation