Two genetic markers closely linked to adult polycystic kidney disease on chromosome 16.
Reeders ST., Breuning MH., Corney G., Jeremiah SJ., Meera Khan P., Davies KE., Hopkinson DA., Pearson PL., Weatherall DJ.
The genetic locus for autosomal dominant adult polycystic kidney disease was recently assigned to chromosome 16 by the finding of genetic linkage to the alpha globin gene cluster. Further study showed that the phosphoglycolate phosphatase locus is also closely linked to both the locus for adult polycystic kidney disease and the alpha globin gene cluster. These findings have important implications for the prenatal and presymptomatic diagnosis of adult polycystic kidney disease and for a better understanding of its pathogenesis.