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Double relapsed and/or refractory multiple myeloma (DRMM), MM that is relapsed and/or refractory to bortezomib and lenalidomide, carries a poor prognosis. The healthcare costs of DRMM have not previously been reported. We analyzed detailed medical resource utilization (MRU) costs, drug costs and outcomes for 39 UK patients receiving standard DRMM therapy. Median OS in this cohort was 5.6 months. The mean cost of DRMM treatment plus MRU until death was £23,472 [range: £1,411-£90,262], split between drug costs £11,191 and other resource use costs £12,281. The cost per assumed quality-adjusted life year (QALY) during DRMM was £66,983. These data provide a standard of care comparison when evaluating the cost-effectiveness of new drugs in DRMM.

Original publication

DOI

10.1371/journal.pone.0136207

Type

Journal article

Journal

PLoS One

Publication Date

2015

Volume

10

Keywords

Aged, Antineoplastic Agents, Bortezomib, Cost-Benefit Analysis, Female, Humans, Lenalidomide, Male, Middle Aged, Multiple Myeloma, Recurrence, Thalidomide, United Kingdom