Association of two DNA polymorphisms in the alpha-globin gene cluster: implications for genetic analysis.
Wainscoat JS., Higgs DR., Kanavakis E., Cao A., Georgiou D., Clegg JB., Weatherall DJ.
A new polymorphic BgI II restriction endonuclease site in the alpha-globin gene complex has been found in Cypriot, Sardinian, and Greek populations. In all cases, this polymorphism is linked to a particular hypervariable region between the zeta 2 and zeta 1 genes. This suggests that these hypervariable regions are stable and will be useful for genetic analysis.