Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Cancer metabolism has received a substantial amount of interest over the past decade. The advances in analytical tools have, along with the rapid progress of cancer genomics, generated an increasingly complex understanding of metabolic reprogramming in cancer. As numerous connections between oncogenic signalling pathways and metabolic activities emerge, the importance of metabolic reprogramming in cancer is being increasingly recognized. The identification of metabolic weaknesses of cancer cells has been used to create strategies for treating cancer, but there are still challenges to be faced in bringing the drugs that target cancer metabolism to the clinic.

Original publication

DOI

10.1038/nature11706

Type

Journal article

Journal

Nature

Publication Date

15/11/2012

Volume

491

Pages

364 - 373

Keywords

Animals, Cell Proliferation, Humans, Lipids, Mitochondria, Neoplasms, Oncogenes, Signal Transduction, Tumor Suppressor Proteins