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Here, we take a snapshot of the high-throughput sequencing platforms, together with the relevant analytical tools, that are available to microbiologists in 2012, and evaluate the strengths and weaknesses of these platforms in obtaining bacterial genome sequences. We also scan the horizon of future possibilities, speculating on how the availability of sequencing that is 'too cheap to metre' might change the face of microbiology forever.

Original publication

DOI

10.1038/nrmicro2850

Type

Journal article

Journal

Nat Rev Microbiol

Publication Date

09/2012

Volume

10

Pages

599 - 606

Keywords

DNA, Bacterial, Genetics, Microbial, Genome, Bacterial, High-Throughput Screening Assays, Molecular Biology