Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Based on the crystal structures of human alpha-GalCer-CD1d and iNKT-alpha-GalCer-CD1d complexes, nonglycosidic analogues of alpha-GalCer were synthesized. They activate iNKT cells resulting in dendritic cell maturation and the priming of antigen-specific T and B cells. Therefore, they are attractive adjuvants in vaccination strategies for cancer and infectious diseases.

Original publication

DOI

10.1002/cmdc.200800354

Type

Journal article

Journal

ChemMedChem

Publication Date

02/2009

Volume

4

Pages

171 - 175

Keywords

Adjuvants, Immunologic, Animals, Cell Line, Glycosides, Humans, Killer Cells, Natural, Mice, Vaccines