Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Linear IgA disease (LAD) is an acquired autoimmune subepidermal bullous disease characterized by the linear deposition of IgA at the basement membrane zone. A minority of cases are induced by drugs, of which the most frequently implicated is vancomycin. The target antigens in idiopathic LAD are heterogeneous, but have not previously been reported in vancomycin-induced LAD. We report three cases, and in two of these we investigated the target antigens. In both we identified IgA antibodies to LAD285 and IgA and IgG antibodies (dual response) to BP180.

Original publication




Journal article


Br J Dermatol

Publication Date





816 - 820


Aged, Aged, 80 and over, Anti-Bacterial Agents, Autoantibodies, Autoantigens, Autoimmune Diseases, Carrier Proteins, Collagen, Cytoskeletal Proteins, Drug Eruptions, Dystonin, Female, Humans, Immunoglobulin A, Nerve Tissue Proteins, Non-Fibrillar Collagens, Skin, Skin Diseases, Vesiculobullous, Vancomycin