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Genome-wide association studies have highlighted a number of genes involved in autophagy, which are of potential importance in the pathogenesis of Crohn's disease (CD). The associated polymorphisms in ATG16L1 and IRGM have been confirmed, and functional studies have begun to shed light on how they link to CD pathogenesis. In this review we consider the most salient aspects of this rapidly expanding field.

Original publication

DOI

10.1002/ibd.21832

Type

Journal article

Journal

Inflamm Bowel Dis

Publication Date

04/2012

Volume

18

Pages

778 - 781

Keywords

Autophagy, Autophagy-Related Proteins, Carrier Proteins, Crohn Disease, Female, GTP-Binding Proteins, Genetic Predisposition to Disease, Humans, Male, Mutation, Polymorphism, Genetic, Polymorphism, Single Nucleotide