Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib.

Rampotas A., Carter-Brzezinski L., Somervaille TCP., Forryan J., Panitsas F., Harrison C., Witherall R., Innes AJ., Wallis L., Butt NM., Psaila B., Mead AJ., Carter M., Godfrey AL., Laing H., Garg M., Francis S., Ewing J., Teh CH., Cowen HB., Dyer P., McConville C., Wadelin F., Sahra A., McGregor A., Kulakov E., McLornan DP., Lambert J.

Nonmelanoma skin cancers (NMSCs) in ruxolitinib-treated patients with myeloproliferative neoplasms behave aggressively, with adverse features and high recurrence. In our cohort, mortality from metastatic NMSC exceeded that from myelofibrosis. Vigilant skin assessment, counseling on NMSC risks, and prospective ruxolitinib-NMSC studies are crucial.

DOI

10.1182/blood.2023022345

Type

Journal article

Journal

Blood

Publication Date

11/01/2024

Volume

143

Pages

178 - 182

Keywords

Humans, Prospective Studies, Myeloproliferative Disorders, Nitriles, Skin Neoplasms, Pyrazoles, Pyrimidines

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