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Epistasis is fast becoming central to the understanding of the complex relationship between genotype and phenotype observed in autoimmune disease. A study in this issue of the European Journal of Immunology uses in-depth analysis of genome-wide mapping by polymorphic microsatellite markers to shed light on the genomic control of autoimmunity and self-tolerance.

Original publication

DOI

10.1002/eji.201141811

Type

Journal article

Journal

Eur J Immunol

Publication Date

08/2011

Volume

41

Pages

2152 - 2154

Keywords

Animals, Antigens, CD, Autoimmune Diseases, Cattle, Epistasis, Genetic, Genetic Predisposition to Disease, Immune Tolerance, Mice, Mice, Knockout, Receptors, Cell Surface, Receptors, IgG, Signaling Lymphocytic Activation Molecule Family Member 1, gamma-Globulins