Toward a better understanding of T cells in cancer.
Oh DY., Fong L., Newell EW., Turk MJ., Chi H., Chang HY., Satpathy AT., Fairfax B., Silva-Santos B., Lantz O.
T cells mediate anti-tumor immune responses and are the key target of immune checkpoint therapy, but they can also promote immune tolerance. A clear understanding of the specific contributions and biology of different T cell subsets is required to fully harness the curative potential of immunotherapies. Experts discuss the state of the field and key challenges for moving forward.