"Ring-Fencing" BRCA1 tumor suppressor activity
Patel KJ., Crossan GP., Hodskinson MRG.
BRCA1 is a crucial human breast and ovarian cancer tumor suppressor gene. The article by Drost et al. in this issue of Cancer Cell together with a recent paper in Science now provide a clearer picture of how this large and complex protein suppresses tumorigenesis. © 2011 Elsevier Inc.