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The processes that normally generate and maintain adaptive immunity and immunological memory are poorly understood, and yet of fundamental importance when infectious diseases place such a major economic and social burden on the world's health and agriculture systems. Defects in these mechanisms also underlie the many forms of human primary immunodeficiency. Identifying these mechanisms in a systematic way is therefore important if we are to develop better strategies for treating and preventing infection, inherited disease, transplant rejection and autoimmunity. In this review we describe a genome-wide screen in mice for the genes important for generating these adaptive responses, and describe two independent DOCK8 mutant mice strains identified by this screen. DOCK 8 was found to play an essential role in humoral immune responses and to be important in the proper formation of the B cell immunological synapse.

Original publication

DOI

10.3233/DMA-2010-0739

Type

Journal article

Journal

Dis markers

Publication Date

2010

Volume

29

Pages

141 - 150

Keywords

Animals, Antibodies, B-Lymphocytes, Disease Models, Animal, Ethylnitrosourea, Genome-Wide Association Study, Germinal Center, Guanine Nucleotide Exchange Factors, Immunity, Humoral, Immunologic Deficiency Syndromes, Immunologic Memory, Immunological Synapses, Male, Mice, Mice, Inbred C57BL, Mutation