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We report the design and optimisation of novel oligonucleotide substrates for a sensitive fluorescence assay for high-throughput screening and functional studies of the DNA repair enzyme, XPF-ERCC1, with a view to accelerating inhibitor and drug discovery.

Original publication

DOI

10.1039/c9cc05476f

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

26/09/2019

Volume

55

Pages

11671 - 11674

Keywords

DNA Repair, DNA-Binding Proteins, Dimerization, Endonucleases, Humans, Oligonucleotides, Substrate Specificity, Temperature