Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion.
O'Callaghan A., O'Brien SG., Ninkovic M., Butcher GP., Foster CS., Walters JR., Roberts IA.
A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.