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The first large-scale genetic study of people in Papua New Guinea has shown that different groups within the country are genetically highly different from each other. Scientists at the Wellcome Trust Sanger Institute, University of Oxford and the Papua New Guinea Institute of Medical Research reveal that the people there have remained genetically independent from Europe and Asia for most of the last 50,000 years, and that people from the country’s isolated highlands region have been completely independent even until the present day. The study, published in Science, also gives insights into how the development of agriculture and cultural events such as the Bronze or Iron Age could affect the genetic structure of human societies. The study used DNA samples collected by Prof John Clegg and Prof Sir David Weatherall in the 1980s, a collection housed at the WIMM.
TiO2 Alternative Coatings for Ferric Pyrophosphate Premixes: Stability and Bioaccessibility Relative to Ferrous Fumarate
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Teichman DL. et al, (2026), Innovative Food Science and Emerging Technologies, 111
FINE-EM-seq: a rapid isothermal amplification method enabling comprehensive methylome profiling of zebrafish early embryos
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Ding C. et al, (2026), Cell Insight, 5
Genome-Wide Single-Nucleotide Resolution Mapping of DNA Damage by Dual Enzyme Cleavage-Assisted Sequencing
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PD-1 signaling and PD-1 blockade-mediated tumor control are established at microvillar T cell contacts.
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Low-dose IL-2 fails to expand Tregs after alemtuzumab: insight into impaired immune tolerance in multiple sclerosis.
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Mezigdomide reverses T-cell exhaustion through degradation of IKZF1/IKZF3 and reinvigoration of cytokine production pathways.
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Chiu H. et al, (2026), Blood
RegVelo: Gene-regulatory-informed dynamics of single cells.
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Wang W. et al, (2026), Cell
Ikaros degradation by mezigdomide reduces T-cell dysfunction and improves the efficacy of antimyeloma T-cell therapies.
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Early-life Wnt4 expressing colon stromal cells orchestrate lifelong mucosal homeostasis via BMP-driven iNKT cell imprinting.
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Lin X. et al, (2026), Nat Commun
Basophils drive the resolution and promote wound healing in adult and aged mice.
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Long-term survival without high cancer risk in a cohort of 24 patients with Apert syndrome.
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Mesenchymal stroma cell-derived stem cell factor mediates cross-species compatibility of the hematopoietic stem cell niche
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Fröbel J. et al, (2026)
Identification of genetic risk loci associated with aquaporin 4-positive neuromyelitis optica spectrum disorder: a genome-wide association study.
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Attfield KE. et al, (2026), Lancet Neurol, 25, 482 - 491
Chromosomal Rearrangements Identified in Three Additional Patients With Generalized Congenital Hypertrichosis With Gingival Hyperplasia Involving the 17q24.2-q24.3 Locus.
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Tenorio-Castano J. et al, (2026), Clin Genet, 109, 904 - 911
DNA-induced conformational changes in SPRTN relieve its auto-inhibitory effect on protease activity.
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Song W. et al, (2026), bioRxiv
Protecting lactoferrin for iron delivery: Effects of matrix composition and iron loading on gastric stability
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TCRbeta1/TCRbeta2 (TRBC1/TRBC2) antibody pair for determining T-cell monotypia as a surrogate for clonality in formalin-fixed paraffin-embedded material.
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Kaistha A. et al, (2026), J Clin Pathol
The lysine-specific demethylase 1 (LSD1) inhibitor bomedemstat in myelofibrosis: results from a phase 1/2 study.
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Gill H. et al, (2026), Blood Adv
BEstimate: a computational tool for the design and interpretation of CRISPR base editing experiments
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Dinçer C. et al, (2026), Genome Biology
Impact of Oral Iron Dosing Regimens on Iron Biomarkers in Pregnancy: Insights from the PANDA Trial.
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Haynes S. et al, (2026), Blood Adv