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Researchers from the MRC-Human Immunology Unit, supported by the NIHR Oxford Biomedical Research Centre, have used an ‘atlas’ of immune cells in the human colon to find evidence of the role of CD8 T cells in inflammatory bowel disease. The findings could pave the way for more targeted treatments for this chronic disorder.
Protecting lactoferrin for iron delivery: Effects of matrix composition and iron loading on gastric stability
Journal article
Blanco-Doval A. et al, (2026), Food Hydrocolloids, 174
A functional overlap between actively transcribed genes and chromatin insulator elements.
Journal article
Cornell LJ. et al, (2026), EMBO J
The 9th International RASopathies Symposium.
Journal article
Castel P. et al, (2026), Am J Med Genet A
Protocol for stable cell line production to express muscle-type nicotinic receptor.
Journal article
Li A. et al, (2026), STAR Protoc, 7
A mechanism to initiate emergency type 2 myelopoiesis.
Journal article
Fagnan A. et al, (2026), Nature
Gain and Loss of FLT3 Mutations in Patients with Acute Myeloid Leukemia: A Noninterventional Cohort Study (CLEVO).
Journal article
Papayannidis C. et al, (2026), Oncol Ther
Expanding the phenotypic spectrum associated with ZIC1 variants: a neurodevelopmental disorder with and without craniosynostosis
Journal article
TWIGG S., (2026), Genetics in Medicine
Single intramuscular injection of self-amplifying RNA of Nppa to treat myocardial infarction.
Journal article
Zhang K. et al, (2026), Science, 391
RLevolution: Unravelling the history of genomic instability through deep reinforcement learning
Journal article
AHMED A., (2026), Royal Society Open Science
Engineering bone-marrow in a dish - a bloody business: Pre-clinical opportunities, translational use-cases, and a call for consensus.
Journal article
North D. et al, (2026), J Thromb Haemost
Artificial Intelligence Mole-Mapping Surveillance Technologies for Clinicians: A Scoping Review (Preprint)
Preprint
Ibrahim H. et al, (2026)
BCR::ABL1-Induced Enhancer Reprogramming Uncovers Hypersensitivity of Ph+B-ALL Cells to Enhancer-Targeting Drugs.
Journal article
Ng HL. et al, (2026), Adv Sci (Weinh)
Context-specific regulatory genetic variation in MTOR dampens neutrophil-T cell crosstalk in pneumonia-associated sepsis.
Journal article
Zhang P. et al, (2026), Nat Commun
comBO: A combined human bone and lympho-myeloid bone marrow organoid for preclinical modeling of hematopoietic disorders.
Journal article
Shen Y. et al, (2026), Cell Stem Cell
FACT safeguards promoter topology by maintaining nucleosomes and restricting chromatin factor spreading
Preprint
Dopico-Fernandez AM. et al, (2026)
Integrative multi-omics defines melanoma drug response networks and ARID1A-dependent resistance mechanisms.
Journal article
Barker CG. et al, (2026), Mol Syst Biol
Facilitators may represent a new class of regulatory elements.
Journal article
Kassouf M. et al, (2026), Curr Opin Genet Dev, 97
Signalome-wide mapping of the NFκB pathway in T-cells reveals novel targets for immunotherapy
Preprint
Clarke J. et al, (2026)
ATRX loss couples genome instability at a G-rich repeat to dysregulation of human alpha-globin expression.
Journal article
Shen Y. et al, (2026), Nat Commun
High-throughput monoclonal gammopathy community monitoring programme.
Journal article
Agarwal G. et al, (2026), Br J Haematol