Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

It is with profound sadness that we learnt of the death of Professor Vincenzo Cerundolo FRS.

Professor Cerundolo was Director of the MRC Human Immunology Unit at the MRC Weatherall Institute of Molecular Medicine, Oxford, Fellow of the Royal Society, Fellow of the Academy of Medical Sciences, Head of Division at Investigative Medicine, Radcliffe Department of Medicine, and Fellow of Merton College.  His work focused on understanding mechanisms of processing and presentation of lipid and peptide antigens to T cells.  There were many seminal findings, including work with Alain Townsend FRS and colleagues, in which it was found that genes in the MHC region encode transporter proteins which translocate peptides for eventual presentation by MHC class I; and in subsequent studies, Enzo went on to lead a study describing a clinical syndrome associated with defective peptide transport. More recently, Enzo helped define the structural and functional basis for the T cell recognition of lipids bound to CD1 molecules, with consequent enhancement of antibody and peptide-specific T cell responses. The collective findings have broad relevance across immunology, including for mechanisms of inflammation, immuno-oncology and vaccination, with key discoveries being taken forward to clinical trials.

Enzo, as he was known among friends and colleagues, was well known and loved for his warm, open and encouraging approach which benefitted so many students, staff, and collaborators across the world.  Many of his previous team members have gone on to lead teams of their own, which was a source of enormous pride.

Prof Cerundolo worked tirelessly and passionately for the benefit of the MRC Human Immunology Unit and built on the work of Andrew McMichael FRS to create a strong collaborative environment with a positive and inclusive culture which has directly contributed to its success. He brought together people from different disciplines and took enjoyment in seeing investigators thrive in such a warm environment. Enzo was held with great affection by those fortunate enough to work with him. He leaves a loving wife and two children, of whom he was very proud. Enzo was particularly happy to have been able to enjoy seeing his daughter marry in 2019 and for his son to have a successful start to university life. He will be greatly missed.

Similar stories

Biotech spinout MiroBio acquired by Gilead Sciences for ~£332m

Co-founded by Prof. Simon Davis, MiroBio focuses on developing therapeutics for inflammatory diseases.

New study shines light on the complex mechanisms of Fetal Growth Restriction in pregnancy

The paper, published in Nature Communications reveals key genes involved in the common developmental disease.

Seven research groups secure LEAF Sustainability Awards

The Laboratory Efficiency Assessment Framework (LEAF) aims to support research groups to embed sustainability into their work.

Playful science at Wheatley and Holton Play and Activity Day 2022

On Saturday 16th July, volunteers from the MRC WIMM talked the science of blood, lab techniques and coding at the Play and Activity Day organised by the Oxfordshire Play Association.

Gold LEAF Award for Kusumbe Lab

The award demonstrates the group's commitment to sustainable science.

Novel all-in-one vaccine developed to tackle future coronavirus threats

Up to $30 million in funding has been announced by the Coalition for Epidemic Preparedness Innovations (CEPI) to bring a new nanoparticle vaccine offering protection against a range of coronaviruses to clinical trial.