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Researchers in the Simmons lab chart the embryonic origins and appearance of diverse intestinal cellular compartments, with important implications for intestinal diseases.
Identification and Masking of Artefactual and Misleading Within-Host Variants in Deep-Sequencing SARS-CoV-2 Data.
Journal article
Anker KM. et al, (2026), Mol Biol Evol
Identifying phenotype-genotype-function coupling in 3D organoid imaging using Shape, Appearance and Motion Phenotype Observation Tool (SPOT).
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Zhou FY. et al, (2026), Nat Commun, 17
Transmission ratio distortion of NF1 mutant alleles in familial Neurofibromatosis type 1.
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Pei Y. et al, (2026), Genet Med
Loss of cellular RNA homeostasis contributes to MDA5 activation during virus infection.
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Sampaio NG. et al, (2026), Nat Immunol
α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson's disease.
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Lam CL. et al, (2026), Nat Commun, 17
Enforcing mTORC1 activity in therapeutic CD4+ T cells promotes persistence but eventual immune exhaustion.
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Sillito F. et al, (2026), J Immunol, 215
Rapid glycolytic metabolism underpins mucosal-associated invariant T cell functional responses to innate cytokines.
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Ryan EK. et al, (2026), J Immunol, 215
Impaired Metabolic Remodeling Characterizes Injured Niches during Post-ischemic Kidney Repair
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Rietjens RGJ. et al, (2026), Journal of the American Society of Nephrology
Gut microbiota restricts intestinal lipid uptake via modulation of bile phosphatidylcholine metabolism in mice.
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Brunner S. et al, (2026), Nat Microbiol, 11, 2349 - 2364
The Thrombopoietin Receptor S264F Mutant Drives MPN with Marrow Fibrosis Through a Dual Mechanism
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MEAD A., (2026), HemaSphere
Resolving hematopoietic stem versus progenitor cell potential in the mouse dorsal aorta by differential Runx1 +110 enhancer activity.
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Anselmi G. et al, (2026), Cell Rep, 45
Nucleophagy as an emerging therapeutic vulnerability in cancer.
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Tribble S. and Ramadan K., (2026), Autophagy, 1 - 3
The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome.
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Boucher AC. et al, (2026), Leukemia
Identification of a novel deeply quiescent neural stem cell population in the subventricular zone: a potential source for brain repair.
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Nath AR. et al, (2026), Cell Discov, 12
The challenge and promise of studying human antigen-specific T cells.
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Farrar S. et al, (2026), Nat Rev Immunol
Transcriptomic analysis of tissue-resident memory T cells of the fallopian tube reveals a precursor immune surveillance network for ovarian cancer prevention.
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Wang L. et al, (2026), Nat Commun
Magrolimab Plus Azacitidine Versus Placebo Plus Azacitidine in Patients With Untreated Higher-Risk Myelodysplastic Syndromes: The Phase III ENHANCE Study.
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Sallman DA. et al, (2026), J Clin Oncol
Immunology of pregnancy and sepsis: shared and specific pathways guiding future precision care.
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Amarasinghe HE. et al, (2026), EBioMedicine, 130