Cookies on this website
We use cookies to ensure that we give you the best experience on our website. If you click 'Continue' we'll assume that you are happy to receive all cookies and you won't see this message again. Click 'Find out more' for information on how to change your cookie settings.

Many congratulations to Prof Ahmed Ahmed and Prof Enzo Cerundolo, winners of the Ovarian Cancer Action International Grand Challenge Award.

Painting of the fallopian tubes © Susan Lockhart CC BY-NC

The £600,000 award will support research on new ways to enhance immune responses for the treatment of ovarian cancer.

Around 7,500 women are diagnosed with ovarian cancer in the UK each year, making it the 6th most common cancer in women. A significant proportion of ovarian cancers harbour tumour infiltrating lymphocytes, suggesting that immunotherapy strategies might improve prognosis. However, checkpoint inhibitor therapies have so far been of limited success, in contrast with other types of cancers such as melanoma. There is therefore an unmet need for the development of complimentary immunotherapeutic strategies.

The project now funded by Ovarian Cancer Action aims to establish a translation-ready therapeutic platform for treating ovarian cancer patients. The project will focus on adoptive T cell therapies, where patient T cells are expanded in vitro and then re-administered to the patient, with the aim of enhancing the immune response to the tumour. Adoptive T cell therapies have shown great promise in ovarian cancer, but specificity and efficacy are still lacking. This project will specifically look at the selection, isolation and expansion of neo-epitope-specific T cells, and will take advantage of the Cerundolo group’s expertise on immunotherapy and the Ahmed group’s work on ovarian cancer genomics and human organoids.

“We are very excited for winning this award. This work will enable us to investigate novel immunotherapeutic approaches for treating ovarian cancer patients.” said Prof Ahmed. The announcement was made at the Ovarian Cancer Action Research Awards Ceremony last week, hosted by the Royal College of Obstetricians and Gynaecologists.

A PhD studentship is currently available to contribute to this project, with an application deadline of the 10th of January. Prospective applicants can find more information about this opportunity here.

 

Prof Ahmed receives the first installment of his Ovarian Cancer Action Award Prof Ahmed receives the first installment of his Ovarian Cancer Action Award

 

Similar stories

New study maps the development of the human intestine

MRC HIU RDM

Researchers in the Simmons lab chart the embryonic origins and appearance of diverse intestinal cellular compartments, with important implications for intestinal diseases.

MRC HIU appoints new Director

MRC HIU RDM

We are pleased to announce that Professor Alison Simmons has been appointed as the new Director of the MRC Human Immunology Unit.

Study uncovers how low blood iron diminishes immune response

MRC HIU NDM RDM

The Drakesmith group finds that low blood serum iron levels can inhibit T-cell and B-cell immune responses to vaccines and infections.

Study finds new human blood disorder

MRC MHU RDM

The Patel Group have discovered a new human disease caused by formaldehyde accumulation in cells

Interferon-b trial shows positive results

COVID-19 MRC HIU NDM

A trial of a new inhaled antiviral drug for COVID-19 has shown positive results and the drug is now moving into a larger international phase 3 trial of hospitalised patients. MRC HIU's Professor Ling-Pei Ho is one of the main co-authors on the paper.

Role-playing computer game helps players understand how vaccines work on a global scale

Centre for Computational Biology MRC HIU RDM

A free game launched today allows players to role-play the deployment of a virtual vaccine to help to halt the global spread of a viral pandemic.