Fasting mimicking diet in diabetic mice partially preserves glomerular endothelial glycocalyx coverage, without changing the diabetic metabolic environment
van der Velden AIM., Koudijs A., Kooijman S., Rietjens RGJ., Sol WMPJ., Avramut MC., Wang G., Rensen PCN., Rabelink TJ., van der Vlag J., van den Berg BM.
Repeated fasting mimicking diet (FMD) partially prevents glomerular damage in a diabetic mouse model; however, although endothelial glycocalyx heparan sulfate contents were preserved, hyaluronan surface expression was reduced in the presence of UDP-glucuronic acid. The weight loss observed was of lean mass, not fat mass, and increased glomerular oxidative stress argue whether such a diet is safe in patients with diabetes.