Philadelphia-negative myeloproliferative neoplasms (MPNs) are an excellent tractable disease model of a number of aspects of human cancer biology, including genetic evolution, tissue-associated fibrosis, and cancer stem cells. In this review, we discuss recent insights into MPN biology gained from the application of a number of new single-cell technologies to study human disease, with a specific focus on single-cell genomics, single-cell transcriptomics, and digital pathology.
Journal article
2021-04-01T00:00:00+00:00
35
279 - 293
14
Digital pathology, Myeloproliferative neoplasm, Single-cell genomics, Fibrosis, Gene Expression Profiling, Genomics, Humans, Myeloproliferative Disorders, Neoplasms, Neoplastic Stem Cells, Single-Cell Analysis